Vegan – The product is made without ingredients produced by or derived from animals
Isotonic-Capable Drinkable Supplements – Easy-to-swallow supplements in liquid form are immediately available to the body for absorption
Quality Standards – GMP Operations and Standardized Ingredients
Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity
Why Choose Isotonix Digestive Enzymes with Probiotics?
Processed foods are the norm these days, not making it any easier for your body to digest and take in all the essential nutrients you need. Foods that would otherwise offer us their own added enzymes to help our bodies absorb more nutrients are increasingly processed, heated for extended shelf life and stripped of vital elements. Other poor eating habits and even aging can also contribute to inhibiting a healthy digestive process. This means our bodies may now need to work harder to absorb essential nutrients to keep us healthy and functioning. Isotonix® Digestive Enzymes with Probiotics was designed to provide your body with enzymes and good bacteria to promote the absorption of nutrients. It utilizes our advanced Isotonix® delivery system to provide you with essential nutrients that promote digestive health. *
This digestive health promoting supplement features a formula of digestive enzymes and probiotics, including DigeZyme®† – a blend of amylase, protease, cellulase, lactase and lipase – and Lactospore®†(Bacillus coagulans). Digestive enzymes help your body break down food to utilize the complete spectrum of nutrients in the food you eat, resulting in a more complete digestive process and better nutritional absorption. The addition of probiotics helps promote a healthy intestinal tract environment. Besides supporting a healthy digestive tract and absorption of nutrients, Isotonix Digestive Enzymes with Probiotics helps maintain epithelial structure and barrier function and supports healthy skin, helps maintain healthy cholesterol levels, supports healthy immune functions, and may help ease occasional stomach upset.*
Isotonix Digestive Enzymes with Probiotics helps keep your digestive health on track! Its unique blend of digestive enzymes and probiotics makes supporting your digestive health efficient and convenient.*
†DigeZyme® and Lactospore® are registered trademarks of the Sabinsa Corporation.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Isotonix Digestive Enzymes Advantage
Isotonix Delivery System
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream.With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
DigeZyme®† [Amylase (98.5 DU±), Protease (600 PC±), Cellulase (110 CU±), Lactase (400 LAC±), Lipase (20 FIP±)]: 100 mg
DigeZyme® is a multienzyme complex composed mainly of amylases (starch hydrolyzing enzymes), proteases (protein hydrolyzing enzymes) and lipases (lipid hydrolyzing enzymes). These digestive enzymes collectively support the breakdown of complex macromolecules into energy sources and promote the release of the nutrient content from the foods we eat. The digestive system naturally produces digestive enzymes. DigeZyme® supplements the gastrointestinal tract with enzymes to adequately support the body’s ability to digest food. In addition to the amylases, proteases, and lipases, DigeZyme® contains two additional digestive enzymes including lactase (lactose hydrolyzing enzyme) and cellulase (cellulose hydrolyzing enzyme).*
Sucrase: 400 SU±
Sucrase is a digestive enzyme secreted by the villi of the epithelium in the small intestine that supports the hydrolysis (chemical breakdown) of sucrose, also known as table sugar, into glucose and fructose. Glucose and fructose can then enter the blood stream and be used for energy.*
Magnesium (Carbonate): 24 mg
Magnesium promotes the normal synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates. Magnesium also promotes cardiovascular health by supporting normal platelet activity, helping to maintain normal cholesterol levels, and helping to maintain the normal regulation of the heart and blood pressure.*
Potassium (Bicarbonate): 90 mg
Potassium is an essential macro-mineral that helps maintain fluid balance. It promotes normal synthesis of glycogen and proteins, as well as the proper release of energy from protein, fat and carbohydrates during metabolism metabolization. Potassium also promotes the normal elimination of wastes and generally contributes to a sense of well-being. Potassium is stored in the muscles.*
Bacillus coagulans (Lactospore®†): 150,000,000 CFU‡
Previously known as Lactobacillus sporogenes, Bacillus coagulans is a lactic acid producing bacteria. Even though it produces lactic acid, it is not a lactic acid bacteria (i.e. lactobacillus). B. coagulans also produce reproductive spores, which sets it apart from many other probiotics.1 It has shown to survive high levels of stomach acid, which means that it arrives to the small intestine as live bacteria so that it may provide health benefits.1 Research has shown B. coagulans to promote digestive and gastrointestinal health.*
†DigeZyme® and Lactospore® are registered trademarks of the Sabinsa Corporation.
±DU, PC, CU, LAC, FIP, SU = Units of enzyme activity
‡CFU = Colony Forming Units
What happens when we eat?
Even before we eat, our body‘s digestive action begins to take place. Simply smelling food activates our salivary glands (“mouth watering”). As the food enters the stomach, the stomach acid and pepsin – the main digestive enzyme in the stomach – work together to begin breaking the food down into material that the small intestine, where most nutrients are absorbed, can use. Enzymes specific to each of the three nutrient groups (carbohydrates, proteins and fats) are released at this stage, further breaking down the food and contributing to the digestive and absorption processes. These processes continue into the large intestine until the nutrients are extracted by the body.
What are digestive enzymes?
Digestive enzymes help your body break down food, allowing the body to optimize its effort to digest proteins from plant and animal sources as well as break down starch, lactose, fats, and nucleic acids (DNA and RNA). The result is a more complete digestive process, resulting in better nutritional absorption. While most enzymes work inside our cells, digestive enzymes operate outside the cells in the gastrointestinal tract.*
What are the different types of digestive enzymes?
There are three basic food enzymes, each specifically targeting the digestion of a different kind of food molecule: Protease, which helps digest proteins, amylase, which helps digest starch, and lipase, which helps digest fats. There are also four specialty enzymes: lactase (helps digest the sugar lactose in dairy products), maltase (helps digest the sugar maltose in foods), sucrase (helps digest table sugar and sugar found in fruits), and cellulase (helps digest cellulose fibers).
Each of these enzymes plays a significant part in the body’s overall health by helping to release specific and necessary nutrients into our bodies.*
What are probiotics?
Probiotics are beneficial bacteria that are widely believed to provide numerous health benefits, including promoting digestive and immune health. Our bodies all contain both “good” and “bad” bacteria in our digestive system. Probiotics are a heavily researched option for maintaining a healthy balance of bacteria. Isotonix® Digestive Enzymes with Probiotics contains the probiotic, Bacillus coagulans. B. coagulans produces lactic acid, but is not considered a lactic acid bacteria.1 *
Is this a vegetarian product?
- Anonymous. Lactobacillus Sporogenes. Alternative Medical Review. 7(4): 340-342, 2002.
- Ashegiano, M., et al. Treatment of Irritable Bowel Syndrome. Minerva Gastroenterologica E Dietologica. 54(4): 359-363, 2006.
- Bourlioux, P., et al. The Intestine and Its Microflora are Partners for the Protection of the host: Report on the Danone Symposium “The Intelligent Intestine,” Held in Paris, June 14, 2002. American Journal of Clinical Nutrition. 78: 675-683, 2003.
- Borovicka, J., et al. Role of Lipase in the Regulation of Postprandial Gastric Acid Secretion and Emptying of Fat in Humans: a Study with Orlistat, a Highly Specific Lipase Inhibitor. Gut. 46: 774-781, 2000.
- Caspary, W. Physiology and Pathophysiology of Intestinal Absorption. American Journal of Clinical Nutrition. 55: 299-308, 1992.
- Casula, G. and Cutting, S. Bacillus Probiotics: Spore Germination in the Gastrointestinal Tract. Applied and Environmental Microbiology. 68(5): 2344-2352, 2002.
- De Vecchi, E. and Drago, L. Lactobacillus Sporogenes or Bacillus Coagulans: Misidentification or Mislabeling? International Journal of Probiotics and Prebiotics. 1(1): 3-10, 2006.
- Du, H., et al. Enzyme Therapy for Lysosomal Acid Lipase Deficiency in the Mouse. Human Molecular Genetics. 10(16): 1639-1648, 2001.
- Du, H., et al. Lysosomal Acid Lipase-deficient Mice: Depletion of White and Brown Fat, Severe Hepatosplenomegaly, and Shortened Life Span. Journal of Lipid Research. 42(4): 489-500, 2001.
- Du, H., et al. Reduction of Atherosclerotic Plaques by Lysosomal Acid Lipase Supplementation. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 147-154, 2004.
- Feinle-Bisset, C., et al. Fat Digestion is Required for Suppression of Ghrelin and Stimulation of Peptide YY and Pancreatic Polypeptide Secretion by Intraduodenal Lipid. American Journal of Physiology: Endocrinology and Metabolism. 289: E948-E953, 2005.
- Heyman, M. Effect of Lactic Acid Bacteria on Diarrheal Diseases. Journal of the American College of Nutrition. 19: 137S-146S, 2000.
- Isolauri, E., et al. Probiotics: a Role in the Treatment of Intestinal Infection and Inflammation? Gut. 50: 54-59, 2002.
- Keller, J. and Layer, P. Human Pancreatic Exocrine Response to Nutrients in Health and Disease. Gut. 54: 1-28, 2005.
- Lee, M., et al. Total Intestinal Lactase and Sucrase Activities Are Reduced in Aged Rats. Journal of Nutrition. 127(7): 1382-1387, 1997.
- Lobmann, R., et al. Proteases and the Diabetic Foot Syndrome: Mechanisms and Therapeutic Implications. Diabetes Care. 28(2): 461-471, 2005.
- Meisel, J. Commensal microbiota modulate gene expression in the skin. Microbiome. 6(1): 20, 2018
- Mohan, J., et al. Preliminary Observations on Effect of Lactobacillus Sporogenes on Serum Lipid Levels in Hypercholesterolemic Patients. Indian Journal of Medical Research. 92: 431-432, 1990.
- Montalto, M., et al. Management and Treatment of Lactose Malabsorption. World Journal of Gastroenterology. 12(2): 187-191, 2006.
- Namoto, K. Prevention of Infections by Probiotics. Journal of Bioscience and Bioengineering. 100(6): 583-592, 2005.
- Nichols, B., et al. The Maltase-Glucoamylase Gene: Common Ancestry to Sucrase-Isomaltase with Complementary Starch Digestion Activities. Proceedings of the National Academy of Sciences of the United States of America. 100(3): 1432-1437, 2003.
- O’Dea, K., et al. Rate of Starch Hydrolysis in Vitro as a Predictor of Metabolic Responses to Complex Carbohydrate In Vivo. American Journal of Clinical Nutrition. 34: 1991-1993, 1981.
- O’Neill, C.A., et al. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays. 38(11): 1167-1176, 2016
- Sanders, M., et al. Sporeformers as Human Probiotics: Bacillus, Sporolactobacillus, and Brevibacillus. Comprehensive Reviews in Food Science and Food Safety. 2: 101- 110, 2003.
- Scotti, E., et al. Exploring the microbiome in health and disease: Implications for toxicology. Toxicology Research and Application. doi: 10.1177/2397847317741884, 2017
- Vaughn, A. R., et al. Skin-gut axis: The relationship between intestinal bacteria and skin health. World Journal of Dermatology. 6(4): 52-58, 2017
- Yu-Jing, F., et al. A Probiotic Treatment Containing Lactobacillus, Bifidobacterium and Enterococcus Improves IBS Symptoms in an Open Label Trial. Journal of Zhejiang University. 7(12): 987-991, 2006
- Zakim, D. and Herman, R. Insulin-Like Activity of Proteases and Phospholipases. American Journal of Clinical Nutrition. 21(10): 1216-1219, 1968.